![]() ![]() ![]() Numerous ER proteins, including BiP (HSPA5), phosphorylated eIF2α (EIF2S1), ATF4, ATF6 and CHOP (DDIT3), were increased abundant, consistent with UPR. In total, 212 differentially abundant proteins were identified. ![]() To gain insight into pathophysiology, we analysed proteome profiles of TAL-enriched outer renal medulla samples from ADTKD- UMOD and control mice by quantitative LC-MS/MS. ‘Autosomal dominant tubulointerstitial kidney disease – UMOD’ (ADTKD- UMOD) is caused by impaired maturation and secretion of mutant uromodulin (UMOD) in thick ascending limb of Henle loop (TAL) cells, resulting in endoplasmic reticulum (ER) stress and unfolded protein response (UPR).
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